gene expression

Saturating the eQTL map in Drosophila: Genome-wide patterns of cis and trans regulation of transcriptional variation in outbred populations
Most genetic polymorphisms associated with complex traits are found in non-coding regions of the genome. Characterizing their effect …
Luisa F. Pallares, Diogo Melo, Scott Wolf, Evan M. Cofer, Varada Abhyankar, Julie Peng, Julien F. Ayroles
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Saturating the eQTL map in Drosophila: Genome-wide patterns of cis and trans regulation of transcriptional variation in outbred populations
Longitudinal sequencing reveals polygenic and epistatic nature of genomic response to selection
Evolutionary adaptation to new environments likely results from a combination of selective sweeps and polygenic shifts, depending on …
Simon K. G. Forsberg, Diogo Melo, Scott W. Wolf, Jennifer K. Grenier, Minjia Tang, Lucas P. Henry, Luisa F. Pallares, Andrew G. Clark, Julien F. Ayroles
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Longitudinal sequencing reveals polygenic and epistatic nature of genomic response to selection
Reassessing the modularity of gene co-expression networks using the Stochastic Block Model
Finding communities in gene co-expression networks is a common first step toward extracting biological insight from such complex …
Diogo Melo, Luisa F. Pallares, Julien F. Ayroles
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Reassessing the modularity of gene co-expression networks using the Stochastic Block Model
From GWAS to signal validation: A novel method for estimating SNP genetic effects while preserving genomic context
Validating associations between genotypic and phenotypic variation remains a challenge, despite advancements in association studies. …
Scott Wolf, Varada Abhyankar, Diogo Melo, Julien F. Ayroles, Luisa F. Pallares
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From GWAS to signal validation: A novel method for estimating SNP genetic effects while preserving genomic context
Characterizing the landscape of gene expression variance in humans
Gene expression variance has been linked to organismal function and fitness but remains a commonly neglected aspect of molecular …
Scott Wolf, Diogo Melo, Kristina M. Garske, Luisa F. Pallares, Amanda J. Lea, Julien F. Ayroles
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Characterizing the landscape of gene expression variance in humans