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Disentangling variational bias: the roles of development, mutation, and selection
The extraordinary diversity and adaptive fit of organisms to their environment depends fundamentally on the availability of variation. …
Haoran Cai
,
Diogo Melo
,
David L. Des Marais
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Reassessing the modularity of gene co-expression networks using the Stochastic Block Model
Finding communities in gene co-expression networks is a common first step toward extracting biological insight from such complex …
Diogo Melo
,
Luisa F. Pallares
,
Julien F. Ayroles
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Saturating the eQTL map in Drosophila melanogaster: genome-wide patterns of cis and trans regulation of transcriptional variation in outbred populations
Decades of genome-wide mapping have shown that most genetic polymorphisms associated with complex traits are found in non-coding …
Luisa F. Pallares
,
Diogo Melo
,
Scott Wolf
,
Evan M Cofer
,
Varada Abhyankar
,
Julie Peng
,
Julien F. Ayroles
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From GWAS to signal validation: A novel method for estimating SNP genetic effects while preserving genomic context
Validating associations between genotypic and phenotypic variation remains a challenge, despite advancements in association studies. …
Scott Wolf
,
Varada Abhyankar
,
Diogo Melo
,
Julien F. Ayroles
,
Luisa F. Pallares
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Characterizing the landscape of gene expression variance in humans
Gene expression variance has been linked to organismal function and fitness but remains a commonly neglected aspect of molecular …
Scott Wolf
,
Diogo Melo
,
Kristina M. Garske
,
Luisa F. Pallares
,
Amanda J. Lea
,
Julien F. Ayroles
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Morphological integration during postnatal ontogeny: implications for evolutionary biology
How covariance patterns of phenotypes change during development is fundamental for a broader understanding of evolution. There is …
Alex Hubbe
,
Fabio A. Machado
,
Diogo Melo
,
Guilherme Garcia
,
Harley Sebastião
,
Arthur Porto
,
James Cheverud
,
Gabriel Marroig
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Measuring the Magnitude of Morphological Integration: The Effect of Differences in Morphometric Representations and the Inclusion of Size
The magnitude of morphological integration is a major aspect of multivariate evolution, providing a simple measure of the intensity of …
Fabio A. Machado
,
Alex Hubbe
,
Diogo Melo
,
Artur Porto
,
Gabriel Marroig
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DOI
How Does Modularity in the Genotype–Phenotype Map Shape Development and Evolution?
Traits do not evolve independently, as genetic and developmental associations affect the variation that is expressed in populations and …
Diogo Melo
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Genomic Perspective on Multivariate Variation, Pleiotropy, and Evolution
Multivariate quantitative genetics provides a powerful framework for understanding patterns and processes of phenotypic evolution. …
Diogo Melo
,
Gabriel Marroig
,
Jason B. Wolf
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The Evolution of Phenotypic Integration: How Directional Selection Reshapes Covariation in Mice
Variation is the basis for evolution, and understanding how variation can evolve is a central question in biology. In complex …
Anna Penna
,
Diogo Melo
,
Sandra Bernardi
,
Maria Inés Oyarzabal
,
Gabriel Marroig
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Modularity: Genes, Development and Evolution
Modularity has emerged as a central concept for evolutionary biology, providing the field with a theory of organismal structure and …
Diogo Melo
,
Arthur Porto
,
James M. Cheverud
,
Gabriel Marroig
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A case study of extant and extinct Xenarthra cranium covariance structure: implications and applications to paleontology
Most of the mammalian diversity is known only from fossils, and only a few of these fossils are well preserved or abundant. This …
Alex Hubbe
,
Diogo Melo
,
Gabriel Marroig
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Modularity and Integration
Morphological integration refers to the relationships and connections among morphological elements, and is empirically recognized by …
Ana Paula Assis
,
Barbara M. A. Costa
,
Daniela M. Rossoni
,
Diogo Melo
,
Gabriel Marroig
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EvolQG - An R Package for Evolutionary Quantitative Genetics
We present an open source package for performing evolutionary quantitative genetics analyses in the R environment for statistical …
Diogo Melo
,
Guilherme Garcia
,
Alex Hubbe
,
Ana Paula Assis
,
Gabriel Marroig
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Fitness Trade-offs Result in the Illusion of Social Success
Cooperation is ubiquitous across the tree of life, from simple microbes to the complex social systems of animals. Individuals cooperate …
Jason Wolf
,
Jennifer A. Howie
,
Katie Parkinson
,
Nicole Gruenheit
,
Diogo Melo
,
Daniel Rozen
,
Christopher R. L. Thompson
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Directional selection can drive the evolution of modularity in complex traits
Modularity is a central concept in modern biology, providing a powerful framework for the study of living organisms on many …
Diogo Melo
,
Gabriel Marroig
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Modularity, Noise, and Natural Selection
Most biological systems are formed by component parts that are to some degree interrelated. Groups of parts that are more associated …
Gabriel Marroig
,
Diogo Melo
,
Guilherme Garcia
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Selection Response Decomposition (SRD): A New Tool for Dissecting Differences and Similarities Between Matrices.
Genetic and phenotypic variance/covariance matrices are a fundamental measure of the amount of variation and the pattern of association …
Gabriel Marroig
,
Diogo Melo
,
Arthur Porto
,
Harley Sebastião
,
Guilherme Garcia
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